Sunday, May 26, 2013

California Institute for Regenerative Medicine awarded Sangamo $6.4M to develop its ZFP-genome editing technology for the treatment of beta-thalassemia (加州再生醫學研究所授予Sangamo公司了$ 6.4M開發其 ZFP 基因組編輯技術治療β-地中海貧血)

How the technology work?




Figure 1: Schematic to demonstrate the position and orientation of binding of a ZFNs pair to a specific DNA sequence to enable generation of a double strand break in the DNA.

ZFN Schematic


Figure 2: Schematic to demonstrate potential outcomes of a double-strand break in DNA generated by a pair of ZFNs, gene disruption, gene correction or DNA insertion.


Original Source: http://www.sangamo.com/technology/zf-nucleases.html

Friday, May 24, 2013

Asteroid Mining Mission Revealed by Planetary Resources, Inc. (行星資源公司的小行星採礦任務揭示)


Rule #1 About Reading Blogs or Using Internet In General (閱讀部落格,或是使用互聯網的#1規則)


NASA and Google co-purchased quantum computer, from a Canadian company called D-Wave (based near Vancouver, BC.) (美國宇航局和谷歌共同購買由一家加拿大溫哥華公司製造的量子電腦,D-Wave.)


Original Source: http://www.nasdaq.com/article/google-and-nasa-make-quantum-leap-with-new-computer-cm248327

Low-Energy Nuclear Reaction (LENR) or Cold Fusion Principle (低能量核反應或冷聚變原理)



The hydrogen ions are sucked into the nickel lattice, and then the lattice is oscillated at a very high frequency (between 5 and 30 terahertz). This oscillation excites the nickel’s electrons, which are forced into the hydrogen ions (protons), forming slow-moving neutrons. The nickel immediately absorbs these neutrons, making it unstable. To regain its stability, the nickel strips a neutron of its electron so that it becomes a proton — a reaction that turns the nickel into copper (atomic number from 28 to 29) and creates a lot of energy in the process.

Original source: http://www.extremetech.com/extreme/149090-nasas-cold-fusion-tech-could-put-a-nuclear-reactor-in-every-home-car-and-plane

Human Embryonic Stem Cells Derived by Somatic Cell Nuclear Transfer (通過體細胞核移植製造幹細胞)




http://www.cell.com/abstract/S0092-8674(13)00571-0

http://pubpeer.com/publications/F0CFE0360002C25DC0BEFE28987D70

http://www.nature.com/news/stem-cell-cloner-acknowledges-errors-in-groundbreaking-paper-1.13060

Thursday, May 23, 2013

Monday, May 20, 2013

Google Launching the Quantum Artificial Intelligence Lab (谷歌推出的量子人工智能實驗室)

http://googleresearch.blogspot.sg/2013/05/launching-quantum-artificial.html



We believe quantum computing may help solve some of the most challenging computer science problems, particularly in machine learning. Machine learning is all about building better models of the world to make more accurate predictions. If we want to cure diseases, we need better models of how they develop. If we want to create effective environmental policies, we need better models of what’s happening to our climate. And if we want to build a more useful search engine, we need to better understand spoken questions and what’s on the web so you get the best answer.

So today we’re launching the Quantum Artificial Intelligence Lab. NASA’s Ames Research Center will host the lab, which will house a quantum computer from D-Wave Systems, and the USRA (Universities Space Research Association) will invite researchers from around the world to share time on it. Our goal: to study how quantum computing might advance machine learning.

Machine learning is highly difficult. It’s what mathematicians call an “NP-hard” problem. That’s because building a good model is really a creative act. As an analogy, consider what it takes to architect a house. You’re balancing lots of constraints -- budget, usage requirements, space limitations, etc. -- but still trying to create the most beautiful house you can. A creative architect will find a great solution. Mathematically speaking the architect is solving an optimization problem and creativity can be thought of as the ability to come up with a good solution given an objective and constraints.

Classical computers aren’t well suited to these types of creative problems. Solving such problems can be imagined as trying to find the lowest point on a surface covered in hills and valleys. Classical computing might use what’s called “gradient descent”: start at a random spot on the surface, look around for a lower spot to walk down to, and repeat until you can’t walk downhill anymore. But all too often that gets you stuck in a “local minimum” -- a valley that isn’t the very lowest point on the surface.

That’s where quantum computing comes in. It lets you cheat a little, giving you some chance to “tunnel” through a ridge to see if there’s a lower valley hidden beyond it. This gives you a much better shot at finding the true lowest point -- the optimal solution.

We’ve already developed some quantum machine learning algorithms. One produces very compact, efficient recognizers -- very useful when you’re short on power, as on a mobile device. Another can handle highly polluted training data, where a high percentage of the examples are mislabeled, as they often are in the real world. And we’ve learned some useful principles: e.g., you get the best results not with pure quantum computing, but by mixing quantum and classical computing.

Can we move these ideas from theory to practice, building real solutions on quantum hardware? Answering this question is what the Quantum Artificial Intelligence Lab is for. We hope it helps researchers construct more efficient and more accurate models for everything from speech recognition, to web search, to protein folding. We actually think quantum machine learning may provide the most creative problem-solving process under the known laws of physics. We’re excited to get started with NASA Ames, D-Wave, the USRA, and scientists from around the world.

Cold Fusion is real? Publication: Indication of anomalous heat energy production in a reactor device

http://arxiv.org/abs/1305.3913

Indication of anomalous heat energy production in a reactor device

An experimental investigation of possible anomalous heat production in a special type of reactor tube named E-Cat HT is carried out. The reactor tube is charged with a small amount of hydrogen loaded nickel powder plus some additives. The reaction is primarily initiated by heat from resistor coils inside the reactor tube. Measurement of the produced heat was performed with high-resolution thermal imaging cameras, recording data every second from the hot reactor tube. The measurements of electrical power input were performed with a large bandwidth three-phase power analyzer. Data were collected in two experimental runs lasting 96 and 116 hours, respectively. An anomalous heat production was indicated in both experiments. The 116-hour experiment also included a calibration of the experimental set-up without the active charge present in the E-Cat HT. In this case, no extra heat was generated beyond the expected heat from the electric input. Computed volumetric and gravimetric energy densities were found to be far above those of any known chemical source. Even by the most conservative assumptions as to the errors in the measurements, the result is still one order of magnitude greater than conventional energy sources.